Endocrine Abstracts

Chronic sub-clinical inflammation is associated with increased risk of diabetes and cardiovascular disease and is particularly observed in patients that have undergone CABG. Resistin, a novel adipocyte derived protein, has been linked with central adiposity, insulin resistance and sub-clinical inflammation and may mediate both systemic and local paracrine pro-inflammatory responses in vivo. As such we investigated serum resistin from CABG patients and examined whether e...

Background: AMH represents a marker of ovarian reserve and is used in monitoring the effects of gonadotoxic drugs. In PCOS is higher and is an indirect marker of hyperandrogenism. In transsexual man(TM), high prevalence of PCOS is described and AMH provide information about ovarian reserve after exposure to testosterone.Objective: To assess the prevalence of PCOS in young TM previously to testosterone treatment, study the evolution of AMH levels and diff...

PTTG transforms cells in vitro, is tumourigenic in vivo and regulates secretion of fibroblast growth factor-2 (FGF-2). Critical to transactivation of FGF-2 is PTTG's SH3 interacting domain which encodes the gene's sole phosphorylation site. We explored the mechanisms through which PTTG stimulates FGF-2 expression and cell transformation using specific mutations resulting in unphosphorylated PTTG (phos-), a mimic of constitutive phosphorylation (phos+), and a disr...

The purpose of the study is to study the prognostic role of NT¬proBNP in patients with diabetes mellitus type 2 associated chronic heart failure (CHF).Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 Group a...

Introduction: Low androgen levels are associated with decreased sexual activity. However, to our knowledge no population based study has evaluated the association between androgen levels and sexual activity in young men.Aim: To evaluate associations between androgen levels and sexual activity in young men.Design: Seven hundred and seventy-three Danish men, aged 20–29 years, underwent clinical and biochemical examination: Total...

The origins and lineages of somatic cells in mammalian ovaries are poorly understood and not universally agreed upon. By clonally-isolating different phenotypes of bovine fetal stromal cells and conducting microarray analysis, we identified markers of different somatic cells. Antibodies to these markers, markers of other known cell types in fetal ovaries and to extracellular matrix were used to examine bovine ovaries (60–300 days of gestation, n=51) by immunohistoc...

Background and aim: Hashimoto’s Thyroiditis pathogenesis remains unclear in spite of many factors currently suggested. Aim of the study was to explore the relationship between hepatocyte growth factor (HGF) and Hashimoto’s Thyroiditis (HT), goiter formation, and to see if HGF levels are adjusted by TSH suppression.Materials and methods: Sixty-one premenopausal women who admitted our department between November 2010-September 2011 were enrolled ...

Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of glucocerebrosidase with consequent massive acumulation of lipid-laden macrophages in various tissues. Estimated life expectancy is about 9 years shorter than for the reference population. Mortality due to macrovascular diseases is higher, and probably associated with metabolic abnormalities found in GD type 1 patients, including decreases in serum adiponectin levels. Because adip...

Abnormal fetal growth remains a problem in pregnancies, complicated by diabetes and is associated with increased maternal and offspring mortality and morbidity. Insulin-like growth factors (IGFs) are important regulators of fetal growth. Their effects are controlled by binding proteins (IGFBPs). IGFBP-1 is particularly important in pregnancy. Phosphorylated IGFBP-1 (pIGFBP-1) has a high affinity for IGF-I and inhibits IGF-I actions, whereas de-phosphhorylated IGFBP-1 has a low...

Background: In mice, a methionine-choline deficient diet (MCDD) causes steatohepatitis and hepatic insulin resistance. In contrast, a simple choline-deficient diet (CDD) causes liver fat accumulation without steatohepatitis, insulin resistance or weight loss. We hypothesised that differences in liver and adipose fatty acid metabolism underlie the contrasting predisposition to steatohepatitis and hepatic insulin resistance.Methods: C57Bl6 mice (male, aged...